钯催化炔酸与烯烃串联碳酯化反应研究
收稿日期: 2015-05-21
修回日期: 2015-06-05
网络出版日期: 2015-06-16
基金资助
国家自然科学基金(Nos. 21102047, 31101221)和中国博士后科学基金(No. 2015M572303)资助项目.
Palladium-Catalyzed Intermolecular Carboesterification of Alkynoic Acids with Alkenes
Received date: 2015-05-21
Revised date: 2015-06-05
Online published: 2015-06-16
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21102047, 31101221) and the China Postdoctoral Science Foundation (No. 2015M572303).
李建晓 , 张振明 , 李春生 , 罗维 , 杨少容 . 钯催化炔酸与烯烃串联碳酯化反应研究[J]. 有机化学, 2015 , 35(10) : 2199 -2204 . DOI: 10.6023/cjoc201505033
An efficient and mild palladium-catalyzed cascade carboesterification has been developed to afford functionalized α-methylene-γ-lactones in moderate to good yields with high regio-and diastereo-selectivities. Their structures were confirmed by IR, 1H NMR, 13C NMR and HRMS. Furthermore, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active α-methylene-γ-lactones.
Key words： palladium-catalyzed; ionic liquids; alkynoic acids; alkenes; carboesterification
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