新型含取代噻二唑环结构的吡唑肟类化合物的合成及生物活性研究
收稿日期: 2015-08-18
修回日期: 2015-09-11
网络出版日期: 2015-09-17
基金资助
国家自然科学基金(Nos. 21202089, 21372135)、元素有机化学国家重点实验室开放课题(No. 201412)、江苏省大学生创新训练计划和南通市科技计划(Nos. AS2013004, AS2014011)资助项目.
Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety
Received date: 2015-08-18
Revised date: 2015-09-11
Online published: 2015-09-17
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province and the Science and Technology Project Fund of Nantong City (Nos. AS2013004, AS2014011).
戴红 , 黄菊华 , 金智超 , 成晓燕 , 黄凯薇 , 凌勇 , 汪清民 , 石玉军 . 新型含取代噻二唑环结构的吡唑肟类化合物的合成及生物活性研究[J]. 有机化学, 2015 , 35(12) : 2617 -2623 . DOI: 10.6023/cjoc201508018
In order to find novel potent pesticide from pyrazole oxime derivatives, a series of new pyrazole oximes carrying substituted thiadiazole moiety were prepared by the introduction of the key thiadiazole backbone into the molecules of pyrazole oximes. The structures of the title compounds were characterized by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data displayed that some of the title compounds showed good insecticidal activities against Aphis craccivora and Nilaparvata lugens. In addition, some target compounds also exhibited certain larvicidal activity against Oriental armyworm.
Key words： substituted thiadiazole; pyrazole oxime; synthesis; biological activity
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