新型含氮杂环结构的1,1-二氯丙烯类化合物的合成及其生物活性
收稿日期: 2015-08-14
修回日期: 2015-09-23
网络出版日期: 2015-10-08
基金资助
国家自然科学基金(Nos. 21202089, 21372135)和南通市科技计划(Nos. AS2013002, AS2014011)资助项目.
Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles
Received date: 2015-08-14
Revised date: 2015-09-23
Online published: 2015-10-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), and the Science and Technology Project Fund of Nantong City (Nos. AS2013002, AS2014011).
戴红 , 葛书山 , 戴宝江 , 李钰 , 施磊 , 李阳 , 方源 , 石玉军 . 新型含氮杂环结构的1,1-二氯丙烯类化合物的合成及其生物活性[J]. 有机化学, 2015 , 35(12) : 2610 -2616 . DOI: 10.6023/cjoc201508015
In search of novel 1,1-dichloropropene compounds with potent bioactivities, a series of novel 1,1-dichloropropene derivatives containing N-heterocycles were synthesized by the strategy of active substructure combination. The structures of the target compounds were confirmed by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay indicated that most of the title compounds showed good larvicidal activity against Oriental armyworm at the concentration of 500 μg/mL. For example, the inhibition rates against Oriental armyworm of compounds 6a, 6b, 6c, 6d, 6e, 6f, 6i, 6l, 6m and 6o were all 100%. Besides, some target compounds displayed certain insecticidal activity against Aphis craccivora at the concentration of 500 μg/mL.
Key words： N-heterocycle; 1,1-dichloropropene; synthesis; bioactivity
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