二碘化镁催化Paal-Knorr反应合成手性吡咯衍生物的方法
收稿日期: 2015-05-25
修回日期: 2015-08-17
网络出版日期: 2015-10-13
基金资助
国家自然科学基金(Nos. 21372203,21272076)、国家大学生创新创业计划(No. 201310337007)和浙江省新苗人才计划(No. 2014R403021)资助项目
A Highly Efficient Paal-Knorr Synthesis of Chiral Pyrrole Derivatives Catalyzed by MgI2
Received date: 2015-05-25
Revised date: 2015-08-17
Online published: 2015-10-13
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21372203, 21272076), the National University Student Innovation Test Plan (No. 201310337007) and the Zhejiang Xinmiao Talent Projects (No. 2014R403021).
报道了二碘化镁催化的2,5-己二酮与多种手性氨基酸酯的Paal-Knorr缩合反应, 制备单吡咯和双吡咯手性衍生物, 该方法反应条件温和、操作简便、收率高、立体选择性好且环境友好.
关键词： 2,5-己二酮; 手性氨基酸酯; 二碘化镁; Paal-Knorr反应; 手性吡咯衍生物
李鹏诚 , 翁国栋 , 张勇东 , 张兴贤 . 二碘化镁催化Paal-Knorr反应合成手性吡咯衍生物的方法[J]. 有机化学, 2016 , 36(2) : 364 -369 . DOI: 10.6023/cjoc201505041
A novel methodology has been developed for the synthesis of N-substituted mono-pyrrole and bis-pyrrole derivatives with a chiral substituent at the nitrogen atom by MgI2-catalyzed Paal-Knorr condensation using esters of amino acids as the source of chirality. This method has some advantages such as mild reaction conditions, simple procedure, good yields, high stereoselectivity and environmental friendliness.
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