3-C位单取代环维黄杨星D衍生物的合成及其抗耐缺氧活性研究
收稿日期: 2015-08-30
修回日期: 2015-10-03
网络出版日期: 2015-10-13
基金资助
西南民族大学研究生创新型科研(No. CX2014SZ60)、西南民族大学中央高校基本科研业务费专项资金(No. 2014NZYQN21)资助项目
Synthesis and Anti-anoxia Activities of 3-C Mono-substituted Cyclovirobuxine D Derivatives
Received date: 2015-08-30
Revised date: 2015-10-03
Online published: 2015-10-13
Supported by
Project supported by the Southwest University for Nationalities Graduate Student Innovative Projects (No. CX2014SZ60), and the Fundamental Research Funds for the Central Universities (No. 2014NZYQN21).
向涛 , 杨鸿均 , 陈程 , 冯豫川 . 3-C位单取代环维黄杨星D衍生物的合成及其抗耐缺氧活性研究[J]. 有机化学, 2016 , 36(2) : 432 -436 . DOI: 10.6023/cjoc201508030
Seven novel cyclovirobuxine D derivatives were designed and synthesized by using cyclovirobuxine D as a starting material. All compounds synthesized were confirmed by 1H NMR, HRMS and IR. Preliminary results of anti-anoxia activity indicated that compounds displayed different degrees of activity, among them the compounds with piperazinyl exhibited higher anti-anoxia activity than others.
Key words： cyclovirobuxine D; synthesis; anti-anoxia activity
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