一种构建吡喃并[2,3-d]嘧啶酮衍生物的简易方法
收稿日期: 2015-09-28
修回日期: 2015-10-26
网络出版日期: 2015-11-06
基金资助
国家自然科学基金(No. 21402124)资助项目.
A Convenient Method to Prepare Pyrano[2,3-d]pyrimidine Derivatives
Received date: 2015-09-28
Revised date: 2015-10-26
Online published: 2015-11-06
Supported by
Project supported by the National Natural Science Foundation of China (No. 21402124).
在浓硫酸催化下, 2-氨基-3-氰基-4H-吡喃类化合物与乙酸酐反应, 较高产率地合成了一系列吡喃并[2,3-d]嘧啶酮衍生物. 该方法反应时间短(10~15 min)、操作简单、后处理方便. 所合成产物的结构经红外光谱、核磁共振谱表征确证, 其中化合物4a和6a的结构还通过X 射线单晶衍射分析确认.
林志兰 , 张俊民 , 高原 . 一种构建吡喃并[2,3-d]嘧啶酮衍生物的简易方法[J]. 有机化学, 2016 , 36(3) : 659 -663 . DOI: 10.6023/cjoc201509037
A series of pyrano[2,3-d]pyrimidine derivatives were synthesized by the reaction of 2-amino-3-cyano-4H-pyrans with acetic anhydride. This method has the advantages of short reaction times (10~15 min), simple operation and convenient post-treatment. All products were fully characterized by IR and 1H NMR spectra. The molecular structures of 4a and 6a were confirmed using single-crystal X-ray analyses.
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