异单叶大黄素及其类似结构茋类化合物的合成方法
收稿日期: 2015-08-27
修回日期: 2015-10-31
网络出版日期: 2015-11-16
基金资助
成都市高新区创新创业人才奖资助项目.
A Method for the Synthesis of the Isorhapontigenin and the Stilbene Compounds in Similar Structures
Received date: 2015-08-27
Revised date: 2015-10-31
Online published: 2015-11-16
Supported by
Project supported by the Award for Innovative Talents in Chengdu High-tech Zone.
赵剑阳 , 郑紫华 , 黄晴菲 , 邓金根 , 朱槿 , 王启卫 . 异单叶大黄素及其类似结构茋类化合物的合成方法[J]. 有机化学, 2016 , 36(3) : 648 -652 . DOI: 10.6023/cjoc201508027
A method for the synthesis of the isorhapontigenin and the stilbene compounds in similar structures was developed. Using 3,5-dihydroxybenzoic acid as starting material, benzyl protecting the phenolic hydroxyl, via the Wittig-Horner reaction to construct the trans stilbene structure, and then debenzylation under the palladium on carbon/ammonium formate system condition, the isorhapontigenin could be obtained in the yield of up to 48%. The catalytic system was successfully applied in the synthesis of a series of hydroxyl stilbene compounds, which could achieve good results. All the reactions worked under mild conditions and obtained in good yield. Furthermore the materials were of cheap and less toxicity. It provided us a simple way to synthesize hydroxyl stilbene compounds in large scale.
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