天然产物BrosimacutinsH和I的对映选择性全合成
收稿日期: 2015-08-24
修回日期: 2015-11-06
网络出版日期: 2015-11-26
基金资助
国家自然科学基金(Nos. 21362025)、教育部"新世纪优秀人才支持计划"(No. NCET-09-0860)资助项目.
First Enantioselective Synthesis of Brosimacutins H and I
Received date: 2015-08-24
Revised date: 2015-11-06
Online published: 2015-11-26
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21362025) and the Program for New Century Excellent Talents in University (No. NCET-09-0860) .
Brosimacutins H和I是从巴西的Brosimum acutifolium Huber树皮中分离出的两个具有相似结构的黄酮类化合物. 此树皮被巴西当地居民作为抗发炎和抗风湿的药物, 并且这两种化合物具有一定的细胞活性. 以廉价的羟苯乙酮和羟苯甲醛为原料完成了黄酮化合物Brosimacutins H和I的对映选择性合成. 所有新化合物的结构都经过NMR, HRMS确认.
关键词： brosimacutin; 异戊烯基黄酮; 查尔酮; 二氢查尔酮; 全合成
叶子平 , 杨金会 , 冯尧 , 马涛 , 牛明杰 . 天然产物BrosimacutinsH和I的对映选择性全合成[J]. 有机化学, 2016 , 36(3) : 547 -554 . DOI: 10.6023/cjoc201508021
Brosimacutins H and I, isolated from the bark of brosimum acutifolium huber, are flavanoid compounds with similar structures. The bark of this plant is used in Brazilian folk medicine as an anti-inflammatory and anti-rheumatic agent, and cellular activities were reported for these two compounds. Herein the first enantio-selective synthesis of brosimacutins H and I from cheap starting material hydroxyl-acetophenone and hydroxyl benzene formaldehyde was reported. All new compounds in this study were confirmed by NMR and HRMS.
Key words： brosimacutin; prenylated flavonoids; chalcone; dihydrochalcones; total synthesis
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