Jiadifenolide的合成研究进展
收稿日期: 2015-11-30
修回日期: 2015-12-29
网络出版日期: 2016-01-07
基金资助
国家自然科学基金(Nos. 21142007, 21272194, 21572187, U1405228)、中央高校基本科研业务费专项资金(No. 20720160025)和教育部长江学者和创新团队发展计划资助项目.
Synthetic Progress of Jiadifenolide
Received date: 2015-11-30
Revised date: 2015-12-29
Online published: 2016-01-07
Supported by
Project supported by the National Natural Science Foundations of China (Nos. 21142007, 21272194, 21572187, U1405228), the Fundamental Research Funds for the Central Universities (No. 20720160025) and the Program for Changjiang Scholars and Innovative Research Team in University.
Jiadifenolide是一个从我国特有药物假地枫皮中分离得到的结构新颖的seco-prezizaanes型倍半萜类化合物, 具有一个高度氧化的五环笼状结构, 7个连续手性中心. 它在较低浓度下有效促进神经元的生长, 被认为是一种小分子营养剂, 具有治疗神经退行性疾病的潜力. 总结了过去五年间关于此分子的合成研究进展.
关键词： jiadifenolide; seco-prezizaanes型倍半萜; 神经营养剂; 神经退行性疾病; 全合成
李林斌 , 沈洋 , 张延东 . Jiadifenolide的合成研究进展[J]. 有机化学, 2016 , 36(3) : 439 -446 . DOI: 10.6023/cjoc201511054
Jiadifenolide, a new seco-prezizaane-type sesquiterpenoid, was isolated from Chinese unique medicine Illicium jiadifengpi. It contains a highly oxygenated cagelike architecture with seven contiguous stereocenters. It displays potent neurotrophic activity at very low concentration and is regarded as a promising lead compound for developing drugs for neurodegenerative diseases. This review summarizes the synthetic efforts towards jiadifenolide in the last five years.
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