3,3-二甲基-二苯基-2,4-氧杂-8,10-氮杂螺[5.5]十一烷-1,5-二酮-9-硫酮衍生物的有效合成
收稿日期: 2015-10-10
修回日期: 2015-12-03
网络出版日期: 2016-01-21
基金资助
国家科技攻关计划(No.2001BA323C)和江西省研究生创新基金(No.YC2015-B023)资助项目.
Efficient One-Pot Synthesis of 3,3-Dimethyl-diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5-dione-9-thione Derivatives
Received date: 2015-10-10
Revised date: 2015-12-03
Online published: 2016-01-21
Supported by
Project supported by the National Science and Technology Project (No. 2001BA323C) and the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023).
许招会 , 周鹏 , 刘德永 . 3,3-二甲基-二苯基-2,4-氧杂-8,10-氮杂螺[5.5]十一烷-1,5-二酮-9-硫酮衍生物的有效合成[J]. 有机化学, 2016 , 36(5) : 1099 -1103 . DOI: 10.6023/cjoc201510009
Six kinds of 3,3-dimethyl-diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]-undecane-1,5-dione-9-thione derivatives were sythesized by the three component one-pot reaction of aromatic aldehydes with thiourea and 2,2-dimethyl-1,3-dio-xane-4,6-dione in the presence of molecular iodine under solvent-free conditions. The results indicated that the yields ranged from 73% to 91% at 80 ℃ for 3.0~6.0 h using 10 mol% iodine (relative to the substrate of 2,2-dimethyl-1,3-dioxane-4,6-dione). Furthermore, the present procedure with high yields was milder conditions and simpler post-treatment process.
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