钯催化的二甲亚砜对炔酰胺的氧化反应:α-酮酰胺衍生物的高效合成方法
收稿日期: 2016-01-03
修回日期: 2016-02-04
网络出版日期: 2016-02-18
基金资助
国家自然科学基金(Nos.U1204204,21172139,21202095)、河南省科技攻关项目(No.142102210635)和河南省高等学校青年骨干教师(No.2015GGJS-126)资助项目.
Palladium Catalyzed Oxidation of Ynamides Using Dimethyl Sulfoxide as Oxidant: A Facile Way to Synthesize α-Ketoamide Derivatives
Received date: 2016-01-03
Revised date: 2016-02-04
Online published: 2016-02-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. U1204204, 21172139, 21202095), the Science and Technology Key Project of Henan Province (No. 142102210635), and the Program for University Key Young Teachers of Henan Province (No. 2015GGJS-126).
孟团结 , 冯翠兰 , 刘澜涛 , 王涛 , 许凯 , 赵文献 . 钯催化的二甲亚砜对炔酰胺的氧化反应:α-酮酰胺衍生物的高效合成方法[J]. 有机化学, 2016 , 36(6) : 1382 -1388 . DOI: 10.6023/cjoc201601003
A series of α-ketoamide derivatives were obtained from the palladium catalyzed oxidation of ynamides using cheap and readily available dimethyl sulfoxide as oxidant and solvent under room temperature. The structures of all products were characterized by 1H NMR, 13C NMR, IR and HRMS. This protocol has some distinct advantages of mild conditions, simple work-up, readily available starting materials and fast reaction rate.
Key words： dimethyl sulfoxide; ynamides; α-ketoamides; synthesis; oxidation
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