无配体钯催化乙醇水溶液中芳基三氟硼酸钾的Suzuki反应
收稿日期: 2016-01-02
修回日期: 2016-01-20
网络出版日期: 2016-02-24
基金资助
国家自然科学基金(Nos.21276043,21421005)及大连理工大学离退休科研基金(No.DUTTX2015102)资助项目.
Palladium-Catalyzed Ligand-Free Suzuki Reaction of Potassium Aryltrifluoroborates in Aqueous Ethanol
Received date: 2016-01-02
Revised date: 2016-01-20
Online published: 2016-02-24
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21276043, 21421005) and the Research Foundation of Dalian University of Technology for Retired Professors (No. DUTTX2015102).
李新民 , 刘春 , 刘超 , 金子林 . 无配体钯催化乙醇水溶液中芳基三氟硼酸钾的Suzuki反应[J]. 有机化学, 2016 , 36(6) : 1341 -1350 . DOI: 10.6023/cjoc201601001
A simple and ligand-free protocol has been developed for the Pd(OAc)2-catalyzed Suzuki reaction of potassium aryltrifluoroborates in aqueous ethanol under air. In the presence of Pd(OAc)2 and 1 equiv. of K2CO3, aryl or heteroaryl halides coupled with various potassium aryltrifluoroborates smoothly to afford the products in high yields with the highest turnover frequency (TOF) up to 4656 h-1, and a series of triphenylamine derivatives were prepared efficiently in this system. In addition, the active catalyst was proved to be the in situ-generated palladium nanoparticles according to TEM analysis and mercury-poisoning test.
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