无溶剂熔融条件下5-[(3-吲哚基)-芳甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮类化合物的绿色合成
收稿日期: 2016-01-10
修回日期: 2016-02-01
网络出版日期: 2016-02-24
基金资助
国家自然科学基金(No.21403100)和辽宁省博士启动基金(No.20141100)资助项目.
Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt
Received date: 2016-01-10
Revised date: 2016-02-01
Online published: 2016-02-24
Supported by
Project supported by the National Natural Science Foundation of China (No. 21403100), and the Doctoral Scientific Research Foundation of Liaoning Province (No. 20141100).
吕成伟, 刘妍杭, 周晓霞 . 无溶剂熔融条件下5-[(3-吲哚基)-芳甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮类化合物的绿色合成[J]. 有机化学, 2016 , 36(6) : 1407 -1411 . DOI: 10.6023/cjoc201601010
An efficient melting method for the synthesis of β-indole derivatives via Yonemitsu reaction was developed successfully using aldehyde, indole and Meldrum's acid as the starting materials and 50 μL water as green promoter without other solvent. A series of 5-[(indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized in 55%~94% yields. The remarkable advantages of this reaction were mild reaction condition, easy operation, tolerant the substrates with diverse functional groups and environment-friendly.
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