介孔分子筛MCM-41固载席夫碱与醋酸锌共催化“一锅法”合成噻唑啉酮衍生物
收稿日期: 2016-01-14
修回日期: 2016-04-02
网络出版日期: 2016-04-15
基金资助
国家自然科学基金（Nos. 21161026，21362036）和新疆自治区研究生科研创新（No. XJGRI2015013）资助项目.
One-Pot Synthesis of 4-Thiazolidinone Derivatives Catalyzed by Zinc Acetate-Schiff Base Complex Immobilized on Mesoporous Molecular Sieve MCM-41
Received date: 2016-01-14
Revised date: 2016-04-02
Online published: 2016-04-15
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21161026, 21362036) and the Postgraduate Innovative Foundation of Xinjiang Autonomous Region (No. XJGRI2015013).
利用介孔分子筛MCM-41固载席夫碱与Zn（OAc）2作为催化剂，“一锅法”简单有效地催化了醛、胺和巯基乙酸合成噻唑啉酮衍生物. 一系列取代的醛和胺被考察，发现此催化剂能够高效地催化此反应，收率最高可达98%. 另外，此类催化剂能够回收再利用，催化循环5次，反应依然可以得到80%的产率.
关键词： 介孔分子筛MCM-41; 席夫碱; 一锅法; 噻唑啉酮; 催化
邢雪建 , 樊馗 , 庞海霞 , 吴阳 , 杨敬辉 , 石伟 , 解正峰 , 惠永海 . 介孔分子筛MCM-41固载席夫碱与醋酸锌共催化“一锅法”合成噻唑啉酮衍生物[J]. 有机化学, 2016 , 36(8) : 1942 -1947 . DOI: 10.6023/cjoc201601014
A new simple and efficient one-pot synthesis of thiazolidinone derivatives via aldehydes, amines and mercaptoacetic acid in the presence of Zn(OAc)2-Schiff base complex immobilized on MCM-41 is described. A variety of aldehydes and amines were engaged in the study and afforded respective thiazolidinones in high yield (up to 98%). Moreover, consistent activity of recovered catalyst was found to be almost same up to five cycles in 80% yield.
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