氮杂糖修饰的蒽醌衍生物的合成及细胞毒性
收稿日期: 2016-02-16
修回日期: 2016-04-26
网络出版日期: 2016-05-03
基金资助
国家自然科学基金（Nos. 21172051，21372059）资助项目.
Synthesis and Cytotoxicity of Azasugar Modified Anthraquinone Derivatives
Received date: 2016-02-16
Revised date: 2016-04-26
Online published: 2016-05-03
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172051, 21372059).
张平竹 , 魏笑 , 刘欢 , 王齐伟 , 马趁 , 戎瑞雪 , 李小六 . 氮杂糖修饰的蒽醌衍生物的合成及细胞毒性[J]. 有机化学, 2016 , 36(8) : 1921 -1925 . DOI: 10.6023/cjoc201602012
In order to develop the anti-tumor agents with high efficiency and low toxicity, a series of novel azasugar modified anthraquinone derivatives have been designed and synthesized by the ammonolysis of N-alkylamino azasugar with rhine and microwave assisted Ullmann coupling reaction of N-alkylamino azasugar with 1-amino-4-bromoanthraquinone-2-sulfonic acid. Their cytotoxic activities against Hela, A549, MCF-7 and MGC-803 cells were preliminarily evaluated.
Key words： anthraquinone; rhein; azasugar; Ullmann coupling; cytotoxicity
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