Spirotryprostatin类生物碱的合成研究进展
收稿日期: 2016-03-18
修回日期: 2016-05-17
网络出版日期: 2016-06-01
基金资助
陕西省教育厅重点实验室（No.2010JS056）资助项目.
Progress in the Synthesis of Spirotryprostatin Alkaloids
Received date: 2016-03-18
Revised date: 2016-05-17
Online published: 2016-06-01
Supported by
Project supported by the Scientific Research Project Item for Key Laboratory of Shaanxi Province Education Department (No.2010JS056).
Spirotryprostatin类生物碱是一类具有螺环吲哚二酮哌嗪结构的生物碱，其结构特点是吲哚部分和二酮哌嗪部分通过一个螺碳原子手性中心相连.由于具有这样特殊的结构使得螺环吲哚二酮哌嗪化合物具有一些生理和药理活性，尤其对细胞周期有较好的抑制活性.近年来，spirotryprostatin类生物碱的合成得到了广泛的研究，根据其结构中螺环手性中心形成的方法不同，对spirotryprostatin类生物碱的全合成研究进展进行综述.
关键词： spirotryprostatin; 螺环吲哚二酮哌嗪; 生物碱; 生物活性; 全合成
马养民 , 范超 . Spirotryprostatin类生物碱的合成研究进展[J]. 有机化学, 2016 , 36(10) : 2380 -2396 . DOI: 10.6023/cjoc201603031
Spirotryprostatin is one of the alkaloids which contains the spiro-indolyl diketopiperazine structure. It is structurally characterized by indole moiety connected to diketopiperazine moiety via the spiro quaternary carbon chiral center. The combination of the structure of spiro-indoyl and diketopiperazine has demonstrated the special physiological and pharmacological activities, especially the excellent inhibitory activity to cell cycle. In recent years, The synthesis of spirotryprostatin has attracted much attention, according to the formation of the spirocyclic chiral center. The total synthetic efforts towards spirotryprostatin alkaloids are presented.
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