白苞裸蒴中两个新的含氮类化合物
收稿日期: 2016-04-06
修回日期: 2016-05-08
网络出版日期: 2016-06-02
基金资助
国家自然科学基金（No.31560102）资助项目.
Two New Nitrogen Compounds from Gymnotheca involucrata
Received date: 2016-04-06
Revised date: 2016-05-08
Online published: 2016-06-02
Supported by
Project supported by the National Natural Sciences Foundation of China (No.31560102).
通过硅胶和MCI柱色谱以及制备液相色谱等分离方法从白苞裸蒴中分离纯化得到6个含氮类化合物，经质谱和核磁共振等波谱技术将其结构分别鉴定为2-（1-羟基-6-甲氧基-4-氧亚基环己-2-烯-1-基）乙腈（1）、10-甲氧基-1-氧杂-3-氮杂螺[4.5]癸-2，6-二烯-8-酮（2）、2-（1-羟基-4-氧亚基环己-2，5-二烯-1-基）乙腈（3）、1-氧杂-3-氮杂螺[4.5]癸-2-烯-8-酮（4）、1-氧杂-3-氮杂螺[4.5]癸-2，6-二烯-8-酮（5）、对羟基苯乙腈（6）.化合物1和2为新的含氮类化合物，化合物3为新的天然产物，其余化合物均为首次从该植物中分离得到.
肖世基 , 徐德林 , 付少彬 , 张茂生 , 丁立生 , 周燕 . 白苞裸蒴中两个新的含氮类化合物[J]. 有机化学, 2016 , 36(10) : 2496 -2498 . DOI: 10.6023/cjoc201604012
By silica gel, MCI column chromatographic and preparative HPLC (high performance liquid chromatography) technologies, six nitrogen compounds were isolated from the whole parts of Gymnotheca involucrata. By using spectroscopic techniques including NMR and MS, these compounds were identified as 2-(1-hydroxy-6-methoxy-4-oxocyclohexa-2-ene- 1-yl)acetonitrile (1), 10-methoxy-1-oxa-3-azaspiro[4.5]dec-2,6-diene-8-one (2), 2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)- acetonitrile (3), 1-oxa-3-azaspiro[4.5]dec-2-ene-8-one (4), 1-oxa-3-azaspiro[4.5]dec-2,6-diene-8-one (5) and 4-hydroxybenzyl acetonitrile (6). Compounds 1 and 2 are new compounds, compound 3 is a new natural product, and compounds 4~6 were isolated from this plant for the first time.
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