新型4'-(N-取代-1-哌嗪基)查尔酮衍生物的合成及其抗肿瘤活性
收稿日期: 2016-05-12
修回日期: 2016-06-20
网络出版日期: 2016-07-15
基金资助
国家自然科学基金（No. 81460624）和云南省教育厅基金（No. 2014Z119）资助项目.
Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives
Received date: 2016-05-12
Revised date: 2016-06-20
Online published: 2016-07-15
Supported by
Project supported by theNational Natural Science Foundation of China(No. 81460624) and the Foundation of Yunnan Province Department of Education(No. 2014Z119).
林玉萍 , 虎春艳 , 郑喜 , 王秀丽 , 万春平 , 毛泽伟 . 新型4'-(N-取代-1-哌嗪基)查尔酮衍生物的合成及其抗肿瘤活性[J]. 有机化学, 2017 , 37(1) : 237 -241 . DOI: 10.6023/cjoc201605021
With the aim of developing new potent anticancer agents,a series of novel 4'-(N-substitued-1-piperazinyl) chalcone derivatives 3a~3j have been designed and synthesized based on the structure of the chalcone by molecular hybridization.The structures were characterized by 1H NMR,13C NMR and HRMS.These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines(Hela,A549 and SGC7901) by the thiazolyl blue tetrazolium bromide(MTT) assay.The result indicated that compounds 3f,3i and 3j were found to be the potent compounds against human tumor cell lines,which are to be lead compounds for further structural modifications and activity research.
Key words： chalcone; piperazine; synthesis; anti-tumor activity
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