3-羟基-6-腙及6-羰基-3-腙胆甾烷的合成及抗肿瘤活性评估
收稿日期: 2016-04-04
修回日期: 2016-06-17
网络出版日期: 2016-08-12
基金资助
国家自然科学基金（Nos. 21562007，21462009）、广西高校科学研究（No. KY2015D077）及有机化学广西高校重点学科资助项目.
Synthesis and Antitumor Activities of Cholestane Derivatives with a Structure of 3-Hydroxy-6-hydrazone or 6-Carbonyl-3-hydrazone
Received date: 2016-04-04
Revised date: 2016-06-17
Online published: 2016-08-12
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21562007, 21462009), the Science Research Project of Guangxi Teachers University (No. KY2015D077) and the Organic Chemistry in Guangxi University Key Disciplines.
崔建国 , 刘畅 , 刘亮 , 甘春芳 , 卢艳 , 陈爽 , 董新 , 黄燕敏 . 3-羟基-6-腙及6-羰基-3-腙胆甾烷的合成及抗肿瘤活性评估[J]. 有机化学, 2016 , 36(12) : 2933 -2940 . DOI: 10.6023/cjoc201604007
Some cholestane hydrazone derivatives with a structure of 3-or 6-hydrazone group were synthesized by different chemical methods using cholesterol as a starting material, and their structures were characterized by IR, NMR and HRMS. The antiproliferative activity of the compounds in vitro was evaluated against human Bel-7404 and SGC-7901 cancer cells. The results showed that the cholestane derivatives with the structure of 3-hydroxy-6-hydrazone exhibited distinct cytotoxicity. The information obtained from the studies is valuable for the design of novel steroidal chemotherapeutic drugs.
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