分离友好的Mitsunobu反应研究进展
Progress in Separation-Friendly Mitsunobu Reactions
Received date: 2016-06-20
Revised date: 2016-07-26
Online published: 2016-08-12
Mitsunobu反应由于反应条件温和、立体选择性好，在有机合成及药物化学研究中被广泛应用.同时，由于氧化膦及肼类等副产物的影响，该反应也是有机合成化学中最难纯化的反应之一.简化分离、提高纯化效率是近年来对Mitsunobu反应改进研究的热点方向.综述了近年来各种简化分离的Mitsunobu反应，重点介绍了各种分离策略的原理、优缺点及在Mitsunobu反应中的应用.希望通过对Mitsunobu反应各种分离策略的介绍，加深读者对基于分离策略的有机合成的了解.
关键词： Mitsunobu反应; 分离策略; 简化分离
戚娜 , 郭键 , 贺耘 . 分离友好的Mitsunobu反应研究进展[J]. 有机化学, 2016 , 36(12) : 2880 -2887 . DOI: 10.6023/cjoc201606029
The Mitsunobu reaction is famous for its mild conditions, good stereoselectivities and extensive applications. But it is also infamous for difficult purification in organic synthetic chemistry, because of the formation of by-products such as phosphine oxide and hydrazine derivatives. To simplify the separation and improve the efficiency of purification is a hot topic in the research of Mitsunobu reaction. Various emerging strategies for product isolation in Mitsunobu reactions are reviewed. Special stress is laid on the principle, advantages and disadvantages of these strategies.
Key words： Mitsunobu reaction; separation strategy; simplified separation
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