(±)-Galbulin和(±)-8,8'-epi-aristoligone的全合成
收稿日期: 2016-06-11
修回日期: 2016-07-20
网络出版日期: 2016-08-22
基金资助
云南省科技厅-昆明医科大学应用基础研究联合专项（No. 2014FB014）资助项目.
Total Synthesis of (±)-Galbulin and (±)-8,8'-Epi-aristoligone
Received date: 2016-06-11
Revised date: 2016-07-20
Online published: 2016-08-22
Supported by
Project supported by the Special Fund of the Applied Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University (No. 2014FB014).
（±）-galbulin和（±）-8，8'-epi-aristoligone属于苯代四氢萘型木脂素类化合物，具有广泛的生物活性.以3，4-二甲氧基苯乙酸为起始原料，采用Horner-Wadsworth-Emmons反应和Friedel-Crafts反应为关键步骤，经8步得到了（±）-galbulin，并通过将（±）-galbulin苄位氧化得到（±）-8，8'-epi-aristoligone.该法操作简单，路线较短，为苯代四氢萘型木脂素化合物的合成提供了参考.
关键词： galbulin; aristoligone; 全合成
王扣 , 秦红波 , 李明明 . (±)-Galbulin和(±)-8,8'-epi-aristoligone的全合成[J]. 有机化学, 2016 , 36(12) : 2928 -2932 . DOI: 10.6023/cjoc201606016
(±)-Galbulin and (±)-8,8'-epi-aristoligone belong to cyclolignan family, and exhibit varieties of bioactivities. Using Horner-Wadsworth-Emmons and Friedel-Crafts reactions as key steps, galbulin has been successfully synthesized in eight steps from 3,4-dimethoxy-phenylacetic acid, and (±)-8,8'-epi-aristoligone was obtained by oxidation of (±)-galbulin. The method is simple and easy to operate, which provides a reference for the synthesis of cyclolignan compounds.
Key words： galbulin; aristoligone; total synthesis
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