CuI促进的多组分一锅法合成3-取代异喹啉衍生物
收稿日期: 2016-06-14
修回日期: 2016-07-20
网络出版日期: 2016-08-25
基金资助
国家自然科学基金（No. 21272091）、华中师范大学中央高校基本科研业务费（No. CCNU15A02014）资助项目.
Copper Mediated One-Pot Multi-Component Synthesis of 3-Substitued Isoquinolines
Received date: 2016-06-14
Revised date: 2016-07-20
Online published: 2016-08-25
Supported by
Project supported by the National Natural Science Foundation of China (No. 21272091) and the Self-determined Research Funds of Central China Normal University from the Colleges' Basic Research and Operation of Ministry of Education (No. CCNU15A02014).
以邻溴苯甲醛和取代端基炔类化合物为原料，叔丁胺为氮源，DMAc为溶剂，CuI作用下，通过微波辐射多组分一锅法简洁、高效地合成了一系列3-取代异喹啉类衍生物，产率在66%~98%之间.此方法为3-芳基异喹啉衍生物的合成提供了一种高效、快速的合成方法.
关键词： 3-芳基异喹啉衍生物; 碘化亚铜; 微波辐射; 多组分反应
张锐 , 潘金环 , 吴琼友 . CuI促进的多组分一锅法合成3-取代异喹啉衍生物[J]. 有机化学, 2016 , 36(12) : 2906 -2911 . DOI: 10.6023/cjoc201606023
In this paper, a CuI mediated one-pot muti-component method for the preparation of isoquinoline derivatives under microwave irradiation was developed by using 2-bromobenzaldehyde and terminal alkynes as starting materials, tert-butyl amine as nitrogen source. This methodology provides one convenient and high efficient approach to the 3-substituted isoquinoline library.
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