无溶剂合成新亚甲胺型叶立德:1-二氨基亚甲基铵(芳基)甲基-4,4-二甲基-2,6-二氧代-1-环己烷化合物
收稿日期: 2016-06-13
修回日期: 2016-08-10
网络出版日期: 2016-09-01
基金资助
江苏师范大学自然科学基金（No. HXKY2015B001）、江苏省优势学科和江苏省品牌专业建设资助项目.
An Efficient Synthesis of New Azomethine Ylide: 1-(Diaminomethyl-eneammonio)(aryl) methyl-4,4-dimethyl-2,6-dioxocyclohexan-1-ide under Solvent-Free Conditions
Received date: 2016-06-13
Revised date: 2016-08-10
Online published: 2016-09-01
Supported by
Project supported by the Natural Science Foundation of Jiangsu Normal University(No. HXKY2015B001), the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Brand Major of Universities in Jiangsu Province.
孟智颖 , 顾萌萌 , 汪梦瑶 , 许静 , 高旭 , 郝甘露 , 荣良策 . 无溶剂合成新亚甲胺型叶立德:1-二氨基亚甲基铵(芳基)甲基-4,4-二甲基-2,6-二氧代-1-环己烷化合物[J]. 有机化学, 2017 , 37(1) : 213 -217 . DOI: 10.6023/cjoc201606021
The zwitterionic compounds 1-(diaminomethyleneammonio)(aryl) methyl-4,4-dimethyl-2,6-dioxocyclohexan-1-ides were synthesized from the reaction of dimedone,aromatic aldehydes and guanidine carbonate catalyzed by NaOH under solvent-free conditions.This is the new type azomethine ylide compound that has not been reported previously.The other advantages of this reaction were simple operation,short reaction time,and environmental friendly.The products were identified by 1H NMR,13C NMR,IR and HRMS,and that of 4a was additionally confirmed by X-ray diffraction analysis.This reported approach is an effective way for the synthesis of azomethine ylide.
Key words： dimedone; guanidine carbonate; azomethine ylide; green synthesis
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