Cu+/I2共同催化的Blaise反应
收稿日期: 2016-04-21
修回日期: 2016-07-07
网络出版日期: 2016-09-06
基金资助
天津市科技创新平台计划(No. 14TXGCCX00017)资助项目.
Blaise Reaction Co-catalyzed by I2 and Cu+
Received date: 2016-04-21
Revised date: 2016-07-07
Online published: 2016-09-06
Supported by
Project supported by the Innovation Platform Program of Tianjin Science and Technology(No. 14TXGCCX00017).
王嫘 , 梁玉霞 , 张宝 , 冯亚青 . Cu+/I2共同催化的Blaise反应[J]. 有机化学, 2017 , 37(1) : 209 -212 . DOI: 10.6023/cjoc201604045
The yield of Blaise reaction of trimethylsilyl protected(S)-4-chloro-3-hydroxylbutyronitrile with tert-butyl bromo zinc acetate is improved nearly 20% by using Cu+ or I2 as a single catalyst.Interestingly,when Cu+ and I2 were used as the co-catalyst,the reaction yield was further improved from 72.1% to 97.0%.These results,which were reasonably explained via the reaction mechanism,not only indicate that the Blaise reaction can be applied more widely,but also provide a simple route for the preparation of the side chain of rosuvastatin and atorvastatin.Moreover,this optimized Blaise reaction provides a new insight into the C-C bond formation.
Key words: Blaise reaction; catalyst; side chain of rosuvastatin
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