α-三氟甲基-α-羟基Weinreb酰胺的合成研究
收稿日期: 2016-06-22
修回日期: 2016-09-12
网络出版日期: 2016-09-19
基金资助
国家自然科学基金（Nos. 21262031，21462037）资助项目.
Synthesis of α-Trifluoromethyl-α-hydroxyl Weinreb Amides
Received date: 2016-06-22
Revised date: 2016-09-12
Online published: 2016-09-19
Supported by
Project supported by the National Natural Science Foundation of China(Nos. 21262031, 21462037).
探索了三氟甲基三甲基硅烷与α-羰基Weinreb酰胺选择性三氟甲基化反应，合成了一系列α-三氟甲基-α-羟基Weinreb酰胺类化合物，并考察了其作为三氟甲基合成砌块与有机金属试剂的反应.
关键词： 三氟甲基化; 三氟甲基三甲基硅烷; α-三氟甲基-α-羟基Weinreb酰胺; 格氏试剂
康娟 , 黄丹凤 , 王克虎 , 苏瀛鹏 , 胡雨来 , 常青 . α-三氟甲基-α-羟基Weinreb酰胺的合成研究[J]. 有机化学, 2017 , 37(1) : 103 -109 . DOI: 10.6023/cjoc201606034
Selective trifluoromethylation of α-oxo-Weinreb amides was explored using trimethyl(trifluoromethyl) silane as fluorinating reagent.A series of α-trifluoromethyl-α-hydroxyl Weinreb amides were successfully synthesized and their reaction with organometallic reagents was investigated.
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