对二茂铁苯甲酰噻二唑类化合物的合成和性质研究
收稿日期: 2016-07-05
修回日期: 2016-09-06
网络出版日期: 2016-09-19
基金资助
国家自然科学基金（No. 21171149）资助项目.
Synthesis and Properties of 4-Ferrocenyl-benzoyl-thiadiazole Derivatives
Received date: 2016-07-05
Revised date: 2016-09-06
Online published: 2016-09-19
Supported by
Project supported by the National Natural Science Foundation of China(No. 21171149).
任亚平 , 刘絮 , 王瑞 , 周元清 , 李标 , 徐琰 , 宋毛平 . 对二茂铁苯甲酰噻二唑类化合物的合成和性质研究[J]. 有机化学, 2017 , 37(1) : 110 -115 . DOI: 10.6023/cjoc201607008
Seven kinds of ferrocenyl-benzoyl-thiadiazole compounds FcL1~FcL7 were synthesized by using 4-ferrocenyl-benzoic and 2-amino-5-aryl-1,3,4-thiadiazole as raw materials.These compounds were characterized by IR,1H NMR and elemental analysis.The crystal structure of FcL4 was determined by X-ray diffraction analysis.The electrochemical research showed that the redox reaction on the surface of electrode was reversible with single electron,and FcL1~FcL7 have a certain redox response to Pb2+ and Zn2+.The antibacterial activity tests indicated that FcL1~FcL7 presented significant activity and selectivity against Fusarium graminearum.FcL5~FcL7 exhibited good inhibition against human esophageal cancer cells in the anticancer activity tests.
Key words： ferrocene; thiadiazole; crystal structure; electrochemistry; biological activity
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