收稿日期: 2016-08-17
修回日期: 2016-10-08
网络出版日期: 2016-11-03
基金资助
国家科技支撑计划（No.2015BAK45B01）资助项目.
Efficient Synthesis of Epilactose
Received date: 2016-08-17
Revised date: 2016-10-08
Online published: 2016-11-03
Supported by
Project supported by the National Science & Technology Pillar Program of China (No. 2015BAK45B01).
王家尧 , 姜锐 , 梁晓梅 , 金淑惠 , 王道全 , 张建军 . 表乳糖的合成研究[J]. 有机化学, 2017 , 37(2) : 375 -384 . DOI: 10.6023/cjoc201608010
Epilactose (4-O-β-D-galactopyranosyl-D-mannose) is a reducing disaccharide with satisfactory prebiotic properties. A superior synthetic methods were confirmed by screening different coupled donors and acceptors which were synthesized from D-mannose and D-galactose, respectively. This route gets 50% overall yields and all the intermediates are easily to be purified, making the route suitable for large scale preparation of the target compound. All the compounds were characterized by NMR and HRMS spectra.
Key words： epilactose; D-mannose; D-galactose; synthesis
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