新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物的设计、合成与生物活性研究
收稿日期: 2016-10-17
修回日期: 2016-12-11
网络出版日期: 2017-01-10
基金资助
国家自然科学青年基金（No.21602118）、天津化学化工协同创新中心资助项目.
Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives
Received date: 2016-10-17
Revised date: 2016-12-11
Online published: 2017-01-10
Supported by
Project Supported by the National Natural Science Foundation of China (No. 21602118), and the Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).
孟祥德 , 周沙 , 解永涛 , 赵毓 , 熊丽霞 , 周莎 , 李正名 . 新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物的设计、合成与生物活性研究[J]. 有机化学, 2017 , 37(4) : 908 -913 . DOI: 10.6023/cjoc201610027
In order to find efficient, low toxicity, eco-friendly insecticides, novel chiral carbon and sulfur phthalic acid diamide derivatives containing pyridine substitute were designed and synthesized for further studying the structure-activity relationship of dual-chiral sulfilimines and sulfoximines. Their structures were confirmed by NMR and HRMS. The preliminary results of biological evaluation showed that the most compounds exhibited moderate larvicidal activity. These results provide a theoretical basis for the study of the dicarboxamide structures containing sulfiliminyl and sulfoximinyl moieties.
Key words： pyridine; phthalic acid diamides; synthesis; insecticidal activity; dual-chiral
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