离子液体中卤代炔烃高效水解制取α-卤代甲基酮的研究
收稿日期: 2016-10-18
修回日期: 2016-12-30
网络出版日期: 2017-01-20
基金资助
湖南省科技厅基金（No.2015WK3003）、湖南省教育厅科研基金（No.14C0405）资助项目.
Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid
Received date: 2016-10-18
Revised date: 2016-12-30
Online published: 2017-01-20
Supported by
Project supported by the Planned Science and Technology Project of Hunan Province (No. 2015WK3003), the Scientific Research Fund of Hunan Provincial Education Department (No. 14C0405).
付文强 , 谭平 , 邓伟 , 向建南 . 离子液体中卤代炔烃高效水解制取α-卤代甲基酮的研究[J]. 有机化学, 2017 , 37(6) : 1501 -1505 . DOI: 10.6023/cjoc201610031
The haloalkynes were hydrolyzed to α-haloketones by sulfuric acid promotion in ionic liquids (ILs) with 85%~94% yields. The ILs-H2SO4 reaction system could be easily recycled (more five times) without any effect for reaction yield. At the same time, a wide scope of substrates haloalkynes were proper in this reaction system and a series of α-chloro/bromo/iodo acetophenones with different substituent (such as methyl, methoxyl, hydroxyl, nitro etc.) and aliphatic α-haloketones have been obtained in good yields.
Key words： ionic liquid; haloalkynes; hydration; α-haloketones; recyclable
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