三种抗坏血酸糖苷的合成及其α-糖苷酶抑制活性
收稿日期: 2016-12-11
修回日期: 2017-01-20
网络出版日期: 2017-02-20
基金资助
国家自然科学基金（No.21402056）和中央高校基本科研业务费专项资金（No.2014QC007）资助项目.
Synthesis and α-Glycosidase Inhibitory Activity of Three Ascorbic Acid Glycosides
Received date: 2016-12-11
Revised date: 2017-01-20
Online published: 2017-02-20
Supported by
Project supported by the National Natural Science Foundation of China (No. 21402056) and the Fundamental Research Funds for the Central Universities (No. 2014QC007).
马济美 , 谢凌云 , 王龙文 , 陈杭炜 , 曾贞 , 陈浩 , 江洪 . 三种抗坏血酸糖苷的合成及其α-糖苷酶抑制活性[J]. 有机化学, 2017 , 37(6) : 1426 -1432 . DOI: 10.6023/cjoc201612037
2-O-(β-D-Glucopyranosyl)-L-ascorbic acid, a natural β-glycoside with ascorbic acid moiety present in Lycium barbarum, and its two analogues were chemically synthesized. Their inhibitory effect on yeast α-glucosidase and α-amylase were investigated with commercially available acarbose as positive control. The biological assays demonstrated the distinct inhibitory effect of these compounds on α-glucosidase activity and weak inhibitory activity against pancreatic α-amylase. The kinetic study indicated that these compounds were competitive inhibitors. These results imply that these three β-glycosides have the potential to be developed as α-glucosidase inhibitors.
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