布朗斯特酸促进的呋喃[2,3-b]喹啉类并环化合物的合成
收稿日期: 2016-12-08
修回日期: 2017-01-19
网络出版日期: 2017-03-03
基金资助
国家自然科学基金（Nos.21272057，21372065）、河南省高等学校青年骨干教师资助计划（No.2014GGJS-049）、河南省教育厅重点研究（Nos.14A150019，14B150042，15A150015）、河南省高校科技创新人才支持计划（No.17HASTIT002）、河南师范大学杰出青年人才培育基金（No.14YR002）资助项目.
Brønsted Acid-Promoted the Synthesis of Furo[2,3-b]quinolines
Received date: 2016-12-08
Revised date: 2017-01-19
Online published: 2017-03-03
Supported by
Project supported by the National Natural Science Foundation of China (Nos.21272057,21372065),the Young Backbone Teachers Fund of Henan Province (No.2014GGJS-049),the Key Project of Henan Provincal Educational Committee (Nos.14A150019,14B150042,15A150015),the Science&Technology Innovation Talents in Universities of Henan Province (No.17HASTIT002),and the Outstanding Young Talent Cultivation Project Funding of Henan Normal University (No.14YR002).
呋喃并喹啉结构单元广泛存在于很多天然产物中.介绍一种在加热的条件下，三氟甲磺酸促进的，通过多取代呋喃衍生物分子内环合反应制备呋喃[2，3-b]喹啉类化合物的方法.该方法具有操作简单、官能团兼容性好、区域选择性好和产品产率较高等优点.
关键词： 布朗斯特酸; 呋喃[2,3-b]喹啉; 三氟甲磺酸; 傅-克反应
张志国 , 郑丹 , 麻娜娜 , 毕晶晶 . 布朗斯特酸促进的呋喃[2,3-b]喹啉类并环化合物的合成[J]. 有机化学, 2017 , 37(7) : 1824 -1829 . DOI: 10.6023/cjoc201612032
The furoquinoline unit is present in many natural products. Here, an approach is presented for the preparing of furo[2,3-b]quinolines from readily available multi-substituted furans in the presence of Brønsted acid via an intramolecular cyclization under the heating conditions. Simple operation, good compatibility, high regioselectivity and morderate yields are the advantages of the method.
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