锡粉促进“一锅法”合成芳基三氟甲基取代高烯丙基酰肼类化合物
收稿日期: 2016-12-13
修回日期: 2017-03-01
网络出版日期: 2017-03-14
基金资助
国家自然科学基金（Nos.21262031，21462037）资助项目.
Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines
Received date: 2016-12-13
Revised date: 2017-03-01
Online published: 2017-03-14
Supported by
Project supported by the National Natural Science Foundation of China (Nos.21262031,21462037).
在三氟化硼乙醚（BF3·OEt2）促进下，以芳基三氟甲基酮、酰肼、烯丙基溴和锡粉为原料，"一锅法"合成了一系列含三氟甲基的高烯丙基酰肼类化合物.该方法具有收率高、适用范围广以及反应操作简便等优点.合成的三氟甲基高烯丙基酰肼类化合物是一类有效的三氟甲基合成砌块，可方便地转化为各类三氟甲基取代的含氮化合物.
关键词： 一锅法; 锡粉; 芳基三氟甲基酮; 三氟甲基高烯丙基酰肼
王克虎 , 王雅琳 , 殷雪娇 , 彭先沙 , 黄丹凤 , 苏瀛鹏 , 胡雨来 . 锡粉促进“一锅法”合成芳基三氟甲基取代高烯丙基酰肼类化合物[J]. 有机化学, 2017 , 37(7) : 1764 -1773 . DOI: 10.6023/cjoc201612042
A series of trifluoromethylated homoallylic N-acylhydrazines were obtained from one-pot reaction of aryl trifluoroketones, acylhydrazines and allyl bromide promoted by tin powder in the presence of boron trifluoride diethyl etherate (BF3·OEt2). The features of this process include good yields, wide substrate scope, mild conditions and easy operation. Trifluoromethylated homoallylic N-acylhydrazines are useful trifluoromethyl building blocks. They can be easily transformed into trifluoromethylated nitrogen-containing compounds.
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