铁催化分子内sp2-C-H键的胺化/芳构化反应合成6-芳基菲啶
收稿日期: 2017-01-30
修回日期: 2017-03-27
网络出版日期: 2017-03-31
基金资助
国家自然科学基金（Nos.21172197和21372201）、浙江工业大学“省重中之重一级学科”开放基金和浙江省新苗人才计划（No.2016R403057）资助项目.
Synthesis of 6-Aryl Phenanthridines via Iron-Catalyzed sp2-C-H Bond Amination/Aromatization Reaction
Received date: 2017-01-30
Revised date: 2017-03-27
Online published: 2017-03-31
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172197, 21372201), the Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology, Zhejiang University of Technology, and the Xin Miao Talents Program of Zhejiang Province (No. 2016R403057).
施冬冬 , 鲍汉扬 , 徐峥 , 刘运奎 . 铁催化分子内sp2-C-H键的胺化/芳构化反应合成6-芳基菲啶[J]. 有机化学, 2017 , 37(5) : 1290 -1294 . DOI: 10.6023/cjoc201701054
With FeCl2 as a catalyst and Selectfluor as an oxidant, an efficient and highly selective synthesis of 6-aryl phenanthridines in one-pot manner has been achieved via an intramolecular sp2-C-H bond amination/aromatization of N-(biphenyl-2-yl(aryl)methyl)benzenesulfonamide derivatives. The optimized reaction conditions were established through systematic investigations of solvents, temperature, catalysts, oxidants and their dosages in the reaction. The present reaction has advantages of simple operation, easy availability of starting materials, the use of inexpensive and low-toxic iron catalyst, and good compatibility of substrates.
Key words： iron catalysis; C-H activation; amination; phenanthridines
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