海洋天然产物呋喃二倍半萜(18S)-variabilin的全合成
收稿日期: 2017-02-08
修回日期: 2017-03-13
网络出版日期: 2017-04-01
基金资助
国家自然科学基金（Nos.21472129，21272163）资助项目.
Total Synthesis of Marine Furanosesterterpene Natural Product, (18S)-Variabilin
Received date: 2017-02-08
Revised date: 2017-03-13
Online published: 2017-04-01
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21472129, 21272163).
（18S）-variabilin是代表性的呋喃二倍半萜海洋天然产物，具有广泛的生物活性.以香叶醇为起始原料，在通过Evans不对称烷基化反应构建关键手性片段的基础上，经关键的Julia-Lythgoe偶联反应和Aldol类型缩合反应，以13步的最长线性步骤完成了（18S）-variabilin的合成.
关键词： variabilin; 呋喃二倍半萜; 不对称全合成
熊维艳 , 赵迎春 , 徐亮 , 季红 . 海洋天然产物呋喃二倍半萜(18S)-variabilin的全合成[J]. 有机化学, 2017 , 37(8) : 2101 -2108 . DOI: 10.6023/cjoc201702007
(18S)-Variabilin is the representative furanosesterterpenes, which exhibits varieties of bioactivities. Starting from geraniol and the key chiral segment prepared via Evans' asymmetric alkylation protocol, (18S)-variabilin has been totally synthesized in the longest linear 13 steps involving Julia-Lythgoe coupling reaction and aldol-type condensation.
Key words： variabilin; furanosesterterpenes; asymmetric total synthesis
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