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2017 , Vol. 37 >Issue 7: 1839 - 1843

DOI: https://doi.org/10.6023/cjoc201702021

研究简报

白喉乌头中二萜生物碱及其拒食活性研究

  • 陈琳 ,
  • 王倩 ,
  • 黄帅 ,
  • 单连海 ,
  • 高峰 ,
  • 周先礼
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  • a. 西南交通大学生命科学与工程学院 成都 610031;
    b. 西南交通大学材料科学与工程学院 成都 610031;
    c. 西华师范大学化学化工学院 南充 637002

收稿日期: 2017-02-16

  修回日期: 2017-03-09

  网络出版日期: 2017-04-01

基金资助

国家自然科学基金（No.81402803）、四川省小分子天然药物创新团队（No.15TD0048）、四川省教育厅项目（No.15ZB0140）、中央高校基本科研业务费专项（No.2682017QY04）资助项目.

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Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity

  • Chen Lin ,
  • Wang Qian ,
  • Huang Shuai ,
  • Shan Lianhai ,
  • Gao Feng ,
  • Zhou Xianli
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  • a. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031;
    b. School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031;
    c. School of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002

Received date: 2017-02-16

  Revised date: 2017-03-09

  Online published: 2017-04-01

Supported by

Project supported by the National Natural Science Foundation of China (No.81402803),the Small Molecule Natural Medicine Innovation Team (No.15TD0048),the Research Foundation for Educational Commission of Sichuan Province (No.15ZB0140) and the Fundamental Research Funds for Central Universities (No.2682017QY04).

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摘要

从白喉乌头（Aconitum leucostomum Vorosch.）中分离得到13个二萜生物碱，采用HR-ESI- MS，1D NMR和2DNMR等波谱技术确定了它们的结构.其中一个为新的C18二萜生物碱：刺乌宁，其余为已知化合物.同时考察了其中12个化合物对甜菜夜蛾3龄幼虫的拒食活性，结果表明化合物氨茴酰基牛扁碱和东乌头定的活性较好（EC50<1mg/cm2），其次是N-acetylsepaconitine，赣乌碱和N-去乙酰高乌甲素（EC50<2 mg/cm2）.

关键词： 乌头属; 白喉乌头; 二萜生物碱; leucostonine; 拒食活性

本文引用格式

陈琳 , 王倩 , 黄帅 , 单连海 , 高峰 , 周先礼 . 白喉乌头中二萜生物碱及其拒食活性研究[J]. 有机化学, 2017 , 37(7) : 1839 -1843 . DOI: 10.6023/cjoc201702021

Abstract

A new C18 diterpenoid alkaloid,leucostonine(1),was isolated from the whole plant of Aconitum leucostomum Vorosch.,together with twelve known diterpenoid alkaloids.Their structures were elucidated on the basis of extensive spectroscopic analysis,including HR-ESI-MS,1D NMR and 2D NMR spectra.12 compounds were tested for their antifeedant activity against larvae of Spodoptera exigua Hiibner.Anthranoyllycoctonine and avadharidine showed considerable potent antifeedant activity(EC50<1 mg/cm2),followed by N-acetylsepaconitine,finaconitine and N-deacetylappaconitine(EC50<2 mg/cm2).

Key words： aconitum; Aconitum leucostomum; diterpenoid alkaloid; leucostonine; antifeedant activity

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