无金属参与的α-羰基二硫缩烯酮的硫甲基化反应
收稿日期: 2017-01-25
修回日期: 2017-03-17
网络出版日期: 2017-04-10
基金资助
国家自然科学基金（Nos.21172197，21372201）、浙江工业大学“省重中之重一级学科”开放基金资助项目.
Metal-Free Thiomethylation of α-Oxoketene Dithioacetals
Received date: 2017-01-25
Revised date: 2017-03-17
Online published: 2017-04-10
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172197, 21372201) and the Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology, Zhejiang University of Technology.
张海峰 , 鲍汉扬 , 徐峥 , 刘运奎 . 无金属参与的α-羰基二硫缩烯酮的硫甲基化反应[J]. 有机化学, 2017 , 37(8) : 2153 -2158 . DOI: 10.6023/cjoc201701048
With dimethyl sulfoxide (DMSO) as a source of thiomethyl group and NH4I as a promotor, the thiomethylation of α-oxoketene dithioacetals has been achieved to afford thiomethylated α-oxoketene dithioacetals in moderate to good yields. The optimized reaction conditions were established through systematic investigations of solvents, temperature, time, promotors and their dosages in the reaction. The present reaction has advantages of easy availability of starting materials, simple operation, good compatibility of substrates, and metal-free reaction conditions.
Key words： DMSO; α-oxoketene dithioacetals; thiomethylation; metal-free
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