钯催化分子内胺化合成苯并噁嗪酮衍生物
收稿日期: 2017-03-06
修回日期: 2017-04-08
网络出版日期: 2017-04-21
基金资助
国家自然科学基金（No.21572149）和国家自然科学青年基金（Nos.21402133，21403148）资助项目.
Facile Synthesis of Benzoxazinone Derivatives via Palladium Catalyzed Intramolecular Amination
Received date: 2017-03-06
Revised date: 2017-04-08
Online published: 2017-04-21
Supported by
Project supported by the National Natural Science Foundation of China (No. 21572149) and the Young National Natural Science Foundation of China (Nos. 21402133, 21403148).
周盼盼 , 管明玉 , 张静宇 , 徐凡 , 赵应声 . 钯催化分子内胺化合成苯并噁嗪酮衍生物[J]. 有机化学, 2017 , 37(8) : 2028 -2033 . DOI: 10.6023/cjoc201703012
Benzoxazinone and its derivatives are well-known as a broad-spectrum of physiological activities compounds. Herein we report a novel approach for the synthesis of benzoxazine derivatives via a N,O-bindentate directing assisted Pd-catalyzed intramolecular amination reactions. Various benzoxazinone derivatives are obtained in moderate to good yields. The directing group can be removed under mild condition, highlighting potential synthetic utility of this method.
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