无催化剂、水相合成5,5-(苯基亚甲基)双(2,2-亚丁基-1,3-二噁烷-4,6-二酮)衍生物
收稿日期: 2017-01-23
修回日期: 2017-04-13
网络出版日期: 2017-04-27
基金资助
国家科技攻关计划（No.2001BA323C）和江西省研究生创新基金（No.YC2015-B023）资助项目.
Synthesis of 5,5-(Phenylmethylene)bis(2,2-butylidene-1,3-dioxane-4,6-dione) Derivatives without Catalyst in Water
Received date: 2017-01-23
Revised date: 2017-04-13
Online published: 2017-04-27
Supported by
Project supported by the National Science and Technology Project (No. 2001BA323C) and the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023).
张文锋 , 许招会 , 涂缘鸿 , 廖传文 . 无催化剂、水相合成5,5-(苯基亚甲基)双(2,2-亚丁基-1,3-二噁烷-4,6-二酮)衍生物[J]. 有机化学, 2017 , 37(9) : 2449 -2453 . DOI: 10.6023/cjoc201701046
A new simple and efficient synthesis of 5,5-(phenylmethylene)bis(2,2-butylidene-1,3-dioxane-4,6-dione) derivatives, based on aromatic aldehydes and 2,2-butylidene-1,3-dioxane-4,6-dione, via Tandem reaction of Knoevenagel condensation and Michael addition is described using water as solvent without catalyst. A variety of aromatic aldehydes were engaged in study and afforded respective products in high yields (63%~83%). The reaction has the advantages of mild conditions, simple operation and environmental friendliness.
Key words： aromatic aldehydes; tandem reaction; synthesis in water; catalyst-free
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