海南暗罗根克罗烷型二萜化学成分研究
收稿日期: 2017-05-23
修回日期: 2017-06-10
网络出版日期: 2017-06-23
基金资助
国家自然科学基金（Nos.81160391，21362009，81360478）、国家国际科技合作专项（No.2014DFA40850）、创新发展团队（No.IRT-16R19）、海南省自然科学基金创新研究团队（No.2016CXTD007）及海南省自然科学基金（No.20162031）资助项目.
Clerodane Diterpenes from the Roots of Polyalthia laui
Received date: 2017-05-23
Revised date: 2017-06-10
Online published: 2017-06-23
Supported by
Project supported by the National Natural Science Foundation of China (Nos.81160391,21362009,81360478),the International S&T Cooperation Program of China (No.2014DFA40850),the Program for Innovative Research Team in University (No.IRT-16R19),the Hainan Provincal Natural Science Foundation of Innovatie Research Team Project (No.2016CXTD007) and the Natural Science Foundation of Hainan Province (No.20162031).
对海南暗罗根化学成分进行系统研究，分离得到5个克罗烷型二萜类化合物.根据它们的NMR和HRMS数据，鉴定它们的结构分别为：（4→2）重排-2，13-二甲酰基-克罗烷-2，12E-二双键-15-甲酯（1）、克罗烷-3，12E-二双键-15，16-二甲酸（2）、14，15-降二碳克罗烷-3-双键-2，13-二酮（3）、克罗烷-3，13Z-二双键-15，16-内酯（4）、16-羟基克罗烷-3，13Z-二双键-15，16-内酯（5）.其中化合物1~2为新化合物.化合物1~5的体外细胞毒活性筛选结果表明，它们对4种肿瘤细胞株（Hela、A549、MCF-7和HL-60）均显示出了一定的体外生长抑制活性，其IC50值范围为13.22~37.16 μmol/L.
李小宝 , 陈光英 , 邵泰明 , 宋小平 , 韩长日 , 余章昕 . 海南暗罗根克罗烷型二萜化学成分研究[J]. 有机化学, 2017 , 37(10) : 2763 -2766 . DOI: 10.6023/cjoc201705035
Five clerodane diterpenes were isolated from the roots of Polyalthia laui during a systematic phytochemical investigation. Their structures were elucidated by the NMR and HRMS data as methyl (4→2)-abeo-2,13-diformyl-cleroda-2,12E-dien-15-ate (1), (E)-ent-cleroda-3,12-diene-15,16-dioic acid (2), 14,15-dinorclerod-3-ene-2,13-dione (3), solidagolactone (4), and 16-hydroxy-3,13Z-kolavadien-16,15-olide (5). Among them, compounds 1~2 are new clerodane diterpenes. Biological evaluation of compounds 1~5 against human Hela, A549, MCF-7 and HL-60 human cancer cell lines showed that all com-pounds displayed moderate cytotoxicities against various human cancer cell lines with IC50 ranged from 13.22 to 37.16 μmol/L.
Key words： Polyalthia laui; clerodane diterpenes; cytotoxicities
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