对羟基苯丙酮酸双加氧酶(HPPD)的结构及其吡唑类除草剂的最新研究进展
收稿日期: 2017-05-21
修回日期: 2017-06-22
网络出版日期: 2017-07-04
基金资助
国家科技支撑计划（No.2014BAD20B01）、国家自然科学资金基金（Nos.21372093，21672079）及中国高校基本科研业务费（No.CCNU15A02011）资助项目.
Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides
Received date: 2017-05-21
Revised date: 2017-06-22
Online published: 2017-07-04
Supported by
Project supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology (No. 2014BAD20B01), the National Natural Science Foundation of China (No. 21372093, 21672079) and the Chinese Universities Basic Scientific Research (No. CCNU15A02011).
对羟基苯丙酮酸双加氧酶（EC 1.13.11.27，HPPD）是重要的除草剂靶标.以HPPD为靶标的除草剂具有高效、低毒、作物安全性高、不易产生抗性、环境相容性好及对后茬作物安全等一系列优点.结合最新的研究进展，详细综述了HPPD的结构，并针对吡唑类HPPD除草剂的作用模式、在生物体内的作用机制和代谢途径以及研究现状进行了总结与分析.
关键词： 对羟基苯丙酮酸双加氧酶; 作用机制; 结合位点; 除草剂
何波 , 王大伟 , 杨文超 , 陈琼 , 杨光富 . 对羟基苯丙酮酸双加氧酶(HPPD)的结构及其吡唑类除草剂的最新研究进展[J]. 有机化学, 2017 , 37(11) : 2895 -2904 . DOI: 10.6023/cjoc201705031
4-Hydroxyphenylpyruvate dioxygenase (HPPD), a target for green herbicide discovery, has recently attracted a large number of famous scientists attention owing to controlling efficacy of resistant weeds. The structures of HPPD, inhibitors binding sites, mode of action and their metabolites are summarized. The current commercial and developing pyrazole-containing herbicides of HPPD are analyzed. Based on combining theory and practical application, a direction to find or design a new inhibitor is also oriented.
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