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2017 , Vol. 37 >Issue 11: 2883 - 2894

DOI: https://doi.org/10.6023/cjoc201705020

综述与进展

螺二萘类天然产物化学研究的新进展

  • 刘鑫磊 ,
  • 赵宇 ,
  • 王卫伟 ,
  • 王明安 ,
  • 周立刚
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  • a 中国农业大学应用化学系 北京 100193;
    b 中国农业大学植物病理系 北京 100193

收稿日期: 2017-05-15

  修回日期: 2017-06-21

  网络出版日期: 2017-07-07

基金资助

国家自然科学基金（No.21172254）资助项目.

收起

Recent Progress of Natural Product Spirobisnaphthalenes

  • Liu Xinlei ,
  • Zhao Yu ,
  • Wang Weiwei ,
  • Wang Ming'an ,
  • Zhou Ligang
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  • a Department of Applied Chemistry, China Agricultural University, Beijing 100193;
    b Department of Plant Pathology, China Agricultural University, Beijing 100193

Received date: 2017-05-15

  Revised date: 2017-06-21

  Online published: 2017-07-07

Supported by

Project supported by the National Natural Science Foundation of China (No. 21172254).

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摘要

螺二萘是一类由两个萘环通过螺缩酮或联二萘醚形式连在一起并高度氧化的天然产物，它们结构新颖复杂、手性中心多，又具有广泛的生物活性，成为近年来合成化学家研究的热门课题.结合本课题组近年来在该领域的研究工作，系统综述了自2010年以来螺二萘类天然产物化学研究取得的新进展，包括新发现的62个天然产物结构、螺二萘类化合物的合成、生物合成途径、生物活性以及结构-活性关系等，旨在进一步推进我国天然产物化学及先导结构优化等在新医药、新农药创制方面的研究工作.

关键词： 螺二萘; 螺缩酮; 天然产物化学; 合成; 生物活性

本文引用格式

刘鑫磊 , 赵宇 , 王卫伟 , 王明安 , 周立刚 . 螺二萘类天然产物化学研究的新进展[J]. 有机化学, 2017 , 37(11) : 2883 -2894 . DOI: 10.6023/cjoc201705020

Abstract

Spirobisnaphthalenes (spirodioxynaphthalenes) are one class of highly oxidized natural products in which two naphthalenes are connected by spiroketal or binaphthalene spiroether. Because of their novel and complex structures, multi-chiral centers and broad bioactivities, synthetic chemists paid a lot of attention to this type of compounds in recent years. The new research progresses of spirobisnaphthalene natural products after 2010 are reviewed based on the results in our laboratory, including 62 new chemical structures, total synthesis and modification, biosynthetic pathway, bioactivities and structure-activity relationships of spirobisnaphthalenes. The objective is to promote the creation of novel drugs and agrochemicals by lead discovery and modification of natural products in China.

Key words： spirobisnaphthalene; spiroketal; natural product; synthesis; bioactivity

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