一步法合成异喹啉酮类化合物
收稿日期: 2017-05-27
修回日期: 2017-07-06
网络出版日期: 2017-07-18
基金资助
国家自然科学基金（Nos.21362042，21662042，U1202221，21262042）、云南省自然科学基金（No.2017FA003）、云南省后备人才（No.2012HB001）、云南大学东陆学者及云南大学青年英才计划（No.XT412003）资助项目.
One-Step Synthesis of Isoquinolinone Compounds
Received date: 2017-05-27
Revised date: 2017-07-06
Online published: 2017-07-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21362042, 21662042, U1202221, 21262042), the Natural Science Foundation of Yunnan Province (No. 2017FA003), the Talent Found in Yunnan Province (No. 2012HB001), the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University (No. XT412003).
王保取 , 孔令斌 , 罗琴 , 林军 , 严胜骄 . 一步法合成异喹啉酮类化合物[J]. 有机化学, 2017 , 37(11) : 2972 -2977 . DOI: 10.6023/cjoc201705038
A concise and efficiently route for the synthesis of isoquinolinones via one-step reaction of nitro substituted methyl 2-fluorobenzoate 1 and heterocyclic ketone aminals (HKAs, 2) in 1,4-dioxane catalyzed by Cs2CO3 under reflux conditions has been developed. Isoquinolinones 3 were obtained by one-step strategy. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.
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