新型含吡唑环结构的吡唑肟酯类化合物的合成与生物活性研究
收稿日期: 2017-07-21
修回日期: 2017-08-21
网络出版日期: 2017-09-08
基金资助
国家自然科学基金（No.21372135）、江苏省“六大人才高峰”（No.2013-SWYY-013）、南通市科技计划（No.MS22015020）资助项目.
Synthesis and Biological Activities of Novel Pyrazole Oxime Esters Containing Substituted Pyrazolyl Group
Received date: 2017-07-21
Revised date: 2017-08-21
Online published: 2017-09-08
Supported by
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (No. MS22015020).
戴红 , 黄美岭 , 葛书山 , 孙思宇 , 沈爱宝 , 成晓燕 , 李春建 , 石健 . 新型含吡唑环结构的吡唑肟酯类化合物的合成与生物活性研究[J]. 有机化学, 2017 , 37(12) : 3289 -3295 . DOI: 10.6023/cjoc201707024
In order to explore novel pyrazole derivatives with good biological activities, a series of pyrazole-containing pyrazole oxime esters were designed and synthesized according to the method of active substructure combination. Their structures were determined by 1H NMR, 13C NMR spectra and elemental analysis. The preliminary bioactivity test showed that some of the target compounds had good insecticidal activity against Aphis medicaginis at a concentration of 500 μg/mL, some title compounds displayed good insecticidal activity against Nilaparvata lugens at 500 μg/mL. In addition, some of the designed compounds exhibited certain anti-tumor activity against HepG2 cells.
Key words： pyrazol; pyrazole oxime; synthesis; bioactivity
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