吡啶乙醇类双[N,O]环钯配合物在Fujiwara-Moritani反应中的高效催化应用
收稿日期: 2017-08-30
修回日期: 2017-09-19
网络出版日期: 2017-09-26
基金资助
国家自然科学基金（Nos.21172200，21302172）资助项目.
Highly Catalytic Activity of Bis(alkoxo)palladium Complexes for Fujiwara-Moritani Reaction
Received date: 2017-08-30
Revised date: 2017-09-19
Online published: 2017-09-26
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172200, 21302172).
在前期工作的基础上，设计合成了一系列吡啶乙醇类双[N，O]环钯配合物，以该类环钯配合物为催化剂，通过Fujiwara-Moritani反应，在相对温和的反应条件下（2 mol%催化剂，30℃，空气环境中）即可高效实现噻吩、呋喃类芳杂环与各类烯烃的偶联，并以中等到高等的分离产率得到相应的目标化合物.进一步通过动力学实验和ESI（+）-MS同步检测，推测该反应是通过协同的金属化/去质子化（CMD）机理进行.
李亚波 , 申振 , 黄萌萌 , 张建业 , Jung Keun Kim , 吴养洁 . 吡啶乙醇类双[N,O]环钯配合物在Fujiwara-Moritani反应中的高效催化应用[J]. 有机化学, 2018 , 38(1) : 200 -207 . DOI: 10.6023/cjoc201708063
A series of bis(alkoxo)palladium complexes (2 mol%) based on pyridine-containing alcohol ligand were tested for Fujiwara-Moritani reaction of thiophenes/furans with various olefins. The desired products were isolated in moderate to excellent yields under mild conditions. A possible concerted metalation-deprotonation (CMD) pathway for this transformation was proved by control experiments and ESI(+)-MS analysis.
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