三核N-杂环卡宾-钯(II)化合物催化芳基氯化物的Buchwald-Hartwig胺化反应研究
收稿日期: 2017-08-18
修回日期: 2017-10-05
网络出版日期: 2017-10-16
基金资助
国家自然科学基金（Nos.U1404205，21572126，21202095）、河南省高校科技创新人才计划（No.14HASTIT016）和河南省重点科技攻关（No.152102410056）资助项目.
Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes
Received date: 2017-08-18
Revised date: 2017-10-05
Online published: 2017-10-16
Supported by
Project supported by the National Natural Sciences Foundation of China (Nos. U1404205, 21572126 and 21202095), the Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 14HASTIT016), Innovation Scientists and Technicians Troop Construction Projects of Henan Province, and Key Scientific and Technological Project of Henan Province (152102410056).
三核N-杂环卡宾-钯（Ⅱ）化合物可以作为芳基氯化物参与的Buchwald-Hartwig胺化反应的有效催化剂前体.在催化剂用量为2.0 mol%的条件下，环状仲胺、芳香伯胺和伯胺与多种芳基氯化物均能顺利地发生胺化反应，以中等至优秀的收率得到目标产物.
关键词： N-杂环卡宾; 三核钯化合物; Buchwald-Hartwig胺化反应; 芳基氯化合物
王涛 , 许凯 , 张安安 , 王万里 , 刘澜涛 . 三核N-杂环卡宾-钯(II)化合物催化芳基氯化物的Buchwald-Hartwig胺化反应研究[J]. 有机化学, 2018 , 38(1) : 259 -265 . DOI: 10.6023/cjoc201708036
The trinuclear N-heterocyclic carbene-palladium(Ⅱ) complexes were found to be the effective catalyst precursors for the Buchwald-Hartwig amination of aryl chlorides. With catalyst loading of 2.0 mol%, the amination of secondary and primary amines with a variety of electronically and structurally diverse aryl chlorides gave the desired products in moderate to excellent yields within hours.
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