[Bmim]ZnBr3促进的烯胺酯和联烯酮的串联反应合成烟酸酯衍生物
收稿日期: 2017-09-13
修回日期: 2017-10-17
网络出版日期: 2017-10-31
基金资助
河南省教育厅自然科学技术研究重点（No.14A150048）资助项目.
[Bmim]ZnBr3-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives
Received date: 2017-09-13
Revised date: 2017-10-17
Online published: 2017-10-31
Supported by
Project supported by the Natural Science Research Program from Education Department of Henan Province (No. 14A150048).
张涛 , 王强 . [Bmim]ZnBr3促进的烯胺酯和联烯酮的串联反应合成烟酸酯衍生物[J]. 有机化学, 2018 , 38(2) : 498 -503 . DOI: 10.6023/cjoc201709019
A novel approach for the synthesis of nicotinate derivatives has been developed by using Lewis acidic ionic liquid[Bmim]ZnBr3, which acts as dual solvent-catalyst in promoting the tandem reaction of enaminoester and allenic ketones. In the reaction process, no catalysts or other organic solvents are used, and[Bmim]ZnBr3 can be readily reused for three times without noticeable decrease in the catalytic activity after simple treatment. Furthermore, our method offers several advantages such as short reaction times, simple work-up procedure, environment-friendly solvent and good yields. The current methodology could also be conveniently applied to the synthesis of natural products and complex therapeutic agents occurring niacin frameworks.
Key words： ionic liquid; enaminoester; allenic ketone; nicotinate
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