铵盐与酰氯的酰胺化合成伯酰胺
收稿日期: 2018-01-24
修回日期: 2018-03-06
网络出版日期: 2018-03-08
基金资助
国家自然科学基金（Nos.21672199，21702197）、中国科学院创新交叉团队、中央高校基本科研业务费专项资金、安徽省自然科学基金（No.1708085MB28）资助项目.
Amidation of Acid Chlorides to Primary Amides with Ammonium Salts
Received date: 2018-01-24
Revised date: 2018-03-06
Online published: 2018-03-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21672199, 21702197), the CAS Interdisciplinary Innovation Team, the Fundamental Research Funds for the Central Universities and the Anhui Provincial Natural Science Foundation (No. 1708085MB28).
李哲健 , 高宝 , 黄汉民 . 铵盐与酰氯的酰胺化合成伯酰胺[J]. 有机化学, 2018 , 38(6) : 1431 -1436 . DOI: 10.6023/cjoc201801034
A practical amidation reaction for the synthesis of primary amides is presented, in which the simple NH4Cl was identified as a practical and convenient amine source. A series of aromatic and aliphatic acid chlorides were successfully compatible with this protocol, affording the corresponding amides in good to excellent yields, which provides a rapid and reliable approach to amides from simple starting materials. Introducing the appropriate N-methyl pyrrolidone (NMP) into the system as solvent and acid-binding reagent plays a key role to avoid the use of stoichiometric amounts of base.
Key words： ammonium salts; amidation; primary amides; acid chlorides; N-methyl pyrrolidone
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