小檗碱与和厚朴酚及槲皮素缀合物的合成及其体外抗肝癌HepG2细胞活性评价
收稿日期: 2018-01-26
修回日期: 2018-02-27
网络出版日期: 2018-03-08
基金资助
国家自然科学基金（Nos.21275036，81202429）资助项目.
Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine
Received date: 2018-01-26
Revised date: 2018-02-27
Online published: 2018-03-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21275036, 81202429).
廖世莉 , 张国改 , 曹涵 , 陈碧莹 , 李卫民 , 吴霞 , 冯毅凡 . 小檗碱与和厚朴酚及槲皮素缀合物的合成及其体外抗肝癌HepG2细胞活性评价[J]. 有机化学, 2018 , 38(6) : 1549 -1555 . DOI: 10.6023/cjoc201801023
Berberine, honokiol, quercetin are the lead compounds with outstanding anti-tumor activities. Three novel products were synthesized from honokiol, quercetin and berberine. The structures of the products were firstly confirmed by 1H NMR, 13C NMR, 2D NMR, HRMS, IR and UV. All products were evaluated for their anti-tumor activities against HepG2 cell in vitro and the results showed that the inhibitory effects of two compounds on HepG2 cell were far superior to honokiol and berberine hydrochloride, and the anti-tumor activities were similar to the reference drug cisplatin. It means that compounds 1 and 2 are expected to be the potential anti-tumor drugs.
Key words： berberine; honokiol; quercetin; anti-tumor activity
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