氧气作为唯一氧化剂的钯催化咖啡因或尿嘧啶C-H键直接芳基化反应
收稿日期: 2018-02-04
修回日期: 2018-03-25
网络出版日期: 2018-04-13
基金资助
国家自然科学基金（No.6152010615）、福建省自然科学基金（No.2017J01572）、福建省教育厅青年重点基金（No.JZ160424）和福建省高校新世纪人才基金和福建师范大学省级大学生创新训练计划（No.201710394061）资助项目.
Palladium-Catalyzed C-H Direct Arylation of Uracils and Caffeines with Arenes Using Molecular Oxygen as the Sole Oxidant
Received date: 2018-02-04
Revised date: 2018-03-25
Online published: 2018-04-13
Supported by
Project supported by the National Natural Science Foundation of China (No. 6152010615), the Natural Science Foundation of Fujian Province (No. 2017J01572), the Foundation of Fujian Educational Committee (No. JZ160424), the Fujian Province University Fund for New Century Excellent Talents, and Undergraduate Training Program for Innovation and Entrepreneurship (No. 201710394061).
潘帼帅 , 吴孔川 , 邓泽颖 , 张馨予 , 张晓凤 , 林深 , 黄秋锋 . 氧气作为唯一氧化剂的钯催化咖啡因或尿嘧啶C-H键直接芳基化反应[J]. 有机化学, 2018 , 38(8) : 2076 -2084 . DOI: 10.6023/cjoc201802008
Palladium-catalyzed cross-dehydrogenative coupling of uracil or caffeine with unactivated arenes has been developed. The approach was characterized by using atmospheric pressure of molecular oxygen as the sole oxidant. Functional groups such as halo, ester, nitro, nitrile and ether are well-tolerated under the reaction conditions. This novel strategy provides a straightforward, facile and economical route to C6-aryl uracil derivatives or C8-aryl caffeine derivatives.
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