氨甲酰基硅烷作为氨酰基源合成α-磺酰氨基酰胺衍生物
收稿日期: 2018-03-30
修回日期: 2018-05-13
网络出版日期: 2018-05-24
基金资助
山西省留学回国人员基金（No.0713）、山西省自然科学基金（No.2012011046-9）和山西师范大学文理学院基金（No.WL2016CXCY-YJ-30）资助项目.
Synthesis of α-(N-Sulfonyl)amino Amides Derivatives Using Carbamoylsilanes as an Amide Source
Received date: 2018-03-30
Revised date: 2018-05-13
Online published: 2018-05-24
Supported by
Project supported by the Shanxi Provincal Foundation for Returness Overseas Scientists (No. 0713), the Natural Science Foundation of Shanxi Province (No. 2012011046-9), and the Foundation of the Modern College of Arts and Science, Shanxi Normal University (No. WL2016CXCY-YJ-30).
韩宇玲 , 仝文婷 , 刘慧 , 陈建新 . 氨甲酰基硅烷作为氨酰基源合成α-磺酰氨基酰胺衍生物[J]. 有机化学, 2018 , 38(8) : 1993 -2001 . DOI: 10.6023/cjoc201803054
α-(N-Sulfonyl)amino amide derivatives are directly synthesized in 71%~89% yields by the reaction of carbamoylsilanes with various N-sulfonylimines in benzene under catalyst-free conditions. The procedure can prepare both tertiary and secondary α-amino amides. A comparison of the results obtained from the N-sulfonylimines containing the variety of alkyl, aryl and heterocyclic ring indicated that the electronic effect was an important factor in the addition reaction, which influenced on the rate and yields of the reaction. The new method is simple and mild procedure, no catalysts conditions, less byproducts and good yields for the preparation of α-aminoamides.
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